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Annexins: The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids.
The antiphospholipid antibody syndrome is due to a deficiency of annexin V. Annexin V normally forms a shield around certain phospholipid molecules that blocks their entry into coagulation (clotting) reactions. In the antiphospholipid antibody syndrome, the formation of this shield is disrupted by the abnormal antibodies. Without the shield, there is an increased quantity of phospholipid molecules on cell membranes, speeding up coagulation reactions and causing the abnormal blood clotting characteristic of the antiphospholipid antibody syndrome.
See also: Annexin A1.
Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins, but recent work suggests a more complex set of functions.
Annexins are multifunctional lipid-binding proteins. Plant annexins are expressed throughout the life cycle and are under environmental control.
Abstract. Annexins are a family of calcium-dependent phospholipid-binding proteins. They are abundant in the eukaryotic kingdom. Though structurally well investigated in ...
Summary. Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins, but recent work suggests a more complex set of functions.
Abstract. Plant annexins are ubiquitous, soluble proteins capable of Ca 2+-dependent and Ca 2+-independent binding to endomembranes and the plasma membrane.