Antiphospholipid antibody syndrome (APLS): An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts (thrombocytopenia).
The abnormal antibodies are directed against phospholipids. (Phospholipids are fats that contains phosphorous). APLS can occur by itself (primary) or be caused by an underlying condition (secondary), such as systemic lupus erythematosus. About a third of persons with primary APLS have heart valve abnormalities.
Antiphospholipid antibodies reduce the levels of annexin V, a protein that binds phospholipids and has potent anticoagulant activity. The reduction of annexin V levels is thought to be a possible mechanism underlying the increased tendency of blood to clot and the propensity to pregnancy loss characteristic of the antiphospholipid antibody syndrome.
The APS Foundation of America, Inc. is the only United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS ...
Read about antiphospholipid syndrome (phospholipid antibody syndrome or Hughes syndrome) symptoms, signs, diagnosis, causes and APS treatment.
Antiphospholipid syndrome is a disorder in which your immune system mistakenly produces antibodies against certain normal proteins in your blood.
What Is Antiphospholipid Antibody Syndrome? Antiphospholipid (AN-te-fos-fo-LIP-id) antibody syndrome (APS) is an autoimmune disorder.
The antiphospholipid antibody syndrome, also known as Hughes Syndrome, is a disorder characterized by multiple different antibodies that are associated ...