APC (gene): A major gene that is involved in causing colorectal cancer. APC is involved in both sporadic and familial forms of colorectal cancer. A mutation in the APC gene is the earliest detectable molecular abnormality in colorectal cancer. This mutation imitates the neoplastic process 20 to 30 years before the malignancy itself is full-blown. APC is a relatively large gene on chromosome 5 in region 5q21-q22. Although a number of different mutations have been identified in the APC gene, most (about 80%) of them cluster in one area of the gene, interrupt its transcription, and truncate (cut off) the transcript. APC stands for adenomatous polyposis coli.
The official name of this gene is â€œadenomatous polyposis coli.â€ APC is the gene's official symbol. The APC gene is also known by other names, listed below.
Complete information for APC gene (protein-coding), adenomatous polyposis coli
APC (gene): A major gene that is involved in causing colorectal cancer. APC is involved in both sporadic and familial forms of colorectal cancer.
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