BRCA2: A gene that normally acts to restrain the growth of cells in the breast and ovary but which, when mutated, may predispose to breast cancer and to ovarian cancer. BRCA2 mutations have also been discovered to be responsible for a significant fraction of early-onset prostate cancer. The first breast cancer genes identified were BRCA1 and BRCA2. Mutations of BRCA1 and BRCA2 account for about half of all cases of inherited breast cancer. These tumors tend to occur in young women. BRCA1 and BRCA2 are usually not involved in breast cancer that is not hereditary.
BRCA2 may regulate the fidelity of cytokinesis, the process by which two daughter cells separate at the completion of cell division. BRCA2 deficiency causes delays in cytokinesis and an increase in the frequency of binucleate cells, a consequence of defective cytokinesis. This role of BRCA2 in daughter cell separation may help to explain why BRCA2 tumor cells often contain alterations in chromosome number (aneuploidy), as well as structurally aberrant chromosomes.
The official name of this gene is â€œbreast cancer 2, early onset.â€ BRCA2 is the gene's official symbol. The BRCA2 gene is also known by other names, listed ...
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for one of these alterations, and consequences of genetic testing. National Cancer ...
It has been estimated that about 5 to 10 percent of all female breast and ovarian cancer cases are hereditary.
Official Symbol BRCA2 provided by HGNC Official Full Name breast cancer 2, early onset provided by HGNC
Cancer Genetics Web www.cancer-genetics.org: Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.