Centric-fusion translocation: A type of chromosome rearrangement, also called a Robertsonian translocation, in which there is fusion of an entire long arm of one acrocentric chromosome with a similarly intact long arm of another acrocentric chromosome. The short arms of the chromosomes participating in the translocation are usually lost.
Acrocentric chromosomes have their centromere near but not at the very end of the chromosome. In humans, chromosomes 13-15, 21 and 22 are acrocentric.
Centric-fusion translocations are relatively common. In balanced form, they take the place of two acrocentric chromosomes and result in no problems. But in unbalanced form, centric-fusion translocations account for some cases of the trisomy 13 (Patau) syndrome and trisomy 21 (Down) syndrome.
Centric-fusion translocation: A type of chromosome rearrangement, also called a Robertsonian translocation, in which there is fusion of an entire long arm of one ...
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Centric-fusion translocation Definition at Online Medical Dictionary. Now you can find here difficult medical language medical terms in easy-to-understand explanations.
[Autoradiographic studies of human chromosomes. VII. 5 cases of familial t(DqDq)] Ann Genet. 1970 Mar; 13(1):19-37. [Ann Genet. 1970] Familial translocation 15-22.
A centric fusion is a translocation in which the centromeres of two acrocentric chromosomes fuse to generate one large metacentric chromosome.