Charcot-Marie-Tooth disease: A genetic disease of nerves characterized by progressively debilitating muscle weakness, particularly of the limbs. The foremost feature is marked wasting of the distal extremities, particularly the peroneal muscle groups in the calves, resulting in "stork legs." The disease usually weakens the legs before the arms. Pes cavus (deformity of the foot) is often the first sign of the disease. Charcot-Marie-Tooth is one of the more frequent genetic diseases and the most common genetic disease of peripheral nerves. Physical therapy can help to delay somewhat the wasting of limbs. The disease is genetically heterogeneous. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked trait. There are also sporadic cases with no family history of the disease that are due to new dominant mutations. Abbreviated CMT. Also known as Chacot-Marie-Tooth hereditary neuropathy, peroneal muscular atrophy, and hereditary motor and sensory neuropathy.
CMT is divided into a large number of types. Molecular genetic knowledge of CMT is evolving. Molecular testing is available for the diagnosis of the following types of CMT:
Jean Charcot (1825-1893) was a celebrated professor of neurology in Paris (and was Sigmund Freud's mentor). Pierre Marie (1853-1940) was also a famous French neurologist. Howard Henry Tooth (1856-1925) was an English physician.
01 Help Joe Paterno Tackle CMT Joe Paterno, Head Football Coach at Penn State, and his wife, Sue, have been getting the word out about CMT. â€¦
What is Charcot-Marie-Tooth disease? What are the symptoms of Charcot-Marie-Tooth disease? What causes Charcot-Marie-Tooth disease? What are the types of Charcot ...
Charcot-Marie-Tooth is one of the most common inherited nerve-related disorders. Defects in at least 14 genes cause different forms of this disease.
Charcot-Marie-Tooth disease is a group of progressive disorders that affect the peripheral nerves and result in problems with movement and sensation.
Definition Charcot-Marie-Tooth disease (CMT) is the name of a group of inherited disorders of the nerves in the peripheral nervous system. These are the nerves ...