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Chargaff rule: The rule that in DNA there is always equality in quantity between the bases A and T and between the bases G and C. (A is adenine, T is thymine, G is guanine, and C is cytosine.) Named for the great Austrian-American biochemist Erwin Chargaff (1905-2002) at Columbia University who discovered this rule. Also known as Chargaff's ratios. Chargaff later said: "This observation of complementarity, later called Chargaff's ratios, was essential to the solution of DNA's structure. In hindsight, the complementary pairing of the nucleotides powerfully suggested that a DNA molecule could break into two parts. Only complementary bases could form bonds and line up in place in a new DNA strand."
The principle that in any sample of DNA the amount of adenine equals the amount of thymine and the amount of guanine equals the amount of cytosine. It is a ...
In the above chart, the amount of Adesine = Thymine and Cytosine = Guanine. Erwin Chargaff’s Rules. In 1950, Erwin Chargaff analysed the base composition ...
Chargaff rule: The rule that in DNA there is always equality in quantity between the bases A and T and between the bases G and C. (A is adenine, T is thymine, G is ...
O f Chargaff's four rules on DNA base composition, only his first parity rule was incorporated into mainstream biology as the DNA double helix.
Chargaff Parity Rule 1. Chargaff Parity Rule 1 holds that a double-stranded DNA molecule globally %A = %T and %G = %C. The rigorous validation of the rule constitutes ...