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Chromosome 11 translocation leukemia: A new type of childhood leukemia in which a piece of chromosome 11 has been translocated (broken off and attached itself to another chromosome). Children with this type of leukemia have a particularly poor prognosis (outlook). They do not respond at all well to the standard therapies for ALL (acute lymphoblastic or lymphocytic leukemia) and often suffer from early relapse after chemotherapy.
Children with chromosome 11 translocation leukemia have gene expression profiles that are different from the profiles of other acute leukemias such as ALL and acute myeloid leukemia.
On both the clinical and laboratory levels, chromosome 11 childhood leukemia appears therefore to be a distinctive disease and not a subset of ALL. Armstrong and coworkers (Nature, Jan 2002) have called it "mixed-lineage leukemia."
Chromosome 11 translocation leukemia: A new type of childhood leukemia in which a piece of chromosome 11 has been translocated (broken off and attached itself to another ...
Short report: Identification of three distinct regions of deletion on the long arm of chromosome 11 in childhood acute lymphoblastic leukemia: Seisho Takeuchi 1, Steve K Cho 1 ...
Two copies of chromosome 11, one copy inherited from each parent, form one of the ... A difficult-to-treat form of childhood leukemia relies on changes in the structure of ...
Characteristics of trisomy 11 in childhood acute leukemia with review of the literature. ... Chromosomes, Human, Pair 11* Female; Humans; Leukemia, Myeloid, Acute/genetics*
Abstract. In a chromosome study in childhood T-cell leukemia/lymphoma, we found t(7;11)(q35;p13) in 2 patients, t(7;14) (q35;q11) in one patient, and t ...