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Definition of «Churg-Strauss syndrome»

Churg-Strauss syndrome: A disease characterized by inflammation of small arteries and veins in persons with a history of asthma or allergy. Aside from the inflammation of blood vessels (angiitis or vasculitis), there are abnormally large number of certain white blood cells (eosinophils) and inflammatory nodular lesions (granulomatosis). Onset is generally between 15 to 70 years of age. Symptoms include fatigue, weight loss, inflammation of the nasal passages, numbness, and weakness. The diagnosis is confirmed by a biopsy of involved tissue. The disease can be severely debilitating and, if untreated, even fatal. Treatment is directed toward both immediately quieting the inflammation of the blood vessels and suppressing the immune system. This may done with high doses of cortisone-related medication (such as prednisone or prednisolone) to calm the inflammation and cyclophosphamide (Cytoxan) to suppress the immune system. The syndrome is named for the American pathologists Jacob Churg (1910-) and Lotte Strauss (1913-85) who first reported it in 1951. Also called allergic granulomatous angiitis.

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