Clark level of invasion: A method for determining the prognosis (outlook) with melanoma. The method was devised by the pathologist Wallace Clark and measures the depth of penetration of a melanoma into the skin according to anatomic layer.
There are five Clark levels of invasion:
Another melanoma measurement system, that of Breslow thickness, named after its originator Alexander Breslow, is in wider use today. In it, invasive tumor thickness is used to predict 5-year survival. For example, a thickness of the melanoma of less than 0.76 millimeters is associated with a 5-year survival of 97% of patients whereas a tumor thickness of more than 8.0 millimeters is associated with 5-year survival of 32%.
Clark level of invasion: A method for determining the prognosis (outlook) with melanoma. The method was devised by the pathologist Wallace Clark and measures the depth of ...
Level V: invasion of the deep, subcutaneous tissue Since 2002, Clark's levels have been used less and less for calculating prognosis, since research has shown ...
... is determined on histologic examination by the vertical thickness of the lesion in millimeters (Breslow classification) and/or the anatomic level of local invasion (Clark ...
Home Chapter Home Jobs Conferences Fellowships Books . Skin-Melanocytic Tumors. Clark’s levels of invasion . Last major update: November 2008 - next update ...
Clark Level; Tumor Vascularity; Lymphovascular Invasion; Microsatellites; Mitotic Rate; Regression; Tumor-Infiltrating Lymphocytes; BRAF Mutations; Distant Metastasis