Complete androgen insensitivity syndrome: A genetic disorder that makes XY fetuses insensitive (unresponsive) to androgens (male hormones). Instead, they are born looking externally like normal girls. Internally there is a short blind-pouch vagina and no uterus, Fallopian tubes, or ovaries. There are testes in the abdomen or the inguinal canal. The complete androgen insensitivity syndrome is usually detected at puberty when a girl should but does not begin to menstrate. The gene for the syndrome is on the X chromosome and codes for the androgen receptor (also called the dihydrotestosterone receptor). There are also partial androgen insensitivity syndrome.