Debride: To remove dead, contaminated or adherent tissue or foreign material. The purpose of wound debridement is to remove all materials that may promote infection and impede healing. This may be done by enzymatic debridement (as with proteolytic enzymes), mechanical nonselective debridement (as in a whirlpool), or sharp debridement (by surgery). Debride comes from the French debrider, to remove the bridle (as from a horse).