DIDMOAD: An acronym that stands for Diabetes Insipidus (inability to concentrate the urine), Diabetes Mellitus, Optic Atrophy (degeneration of the nerve to the eye), and Deafness. These features are characteristic of this genetic disease which is also called the Wolfram syndrome. Patients usually also suffer from severe abnormalities of the nervous system that can be accompanied by behavior problems, psychiatric hospitalizations and, in about a quarter of cases, suicide attempts.
The DIDMOAD or Wolfram syndrome is inherited as an autosomal recessive trait so that brothers and sisters of a child with the syndrome each have a 25 percent chance of receiving the gene from both parents and having the syndrome. The syndrome is caused by a mutation in the gene responsible for the production of a protein called wolframin, resulting in loss of function of this protein. The gene is in chromosome 4p16.1.
Wolfram syndrome is genetically heterogeneous (mixed). There is, for example, a type of Wolfram syndrome with additional atypical features such as profound upper gastrointestinal ulceration and bleeding as well as an absence of diabetes insipidus. The gene for this type of Wolfram syndrome is not in the region of chromosome 4p16.1 but rather is in chromosome 4q22-24.
This site is intended to aid those who are affected by Wolfram Syndrome (DIDMOAD). This is not a scientific or medical information site, but an information site ...
DIDMOAD: An acronym that stands for D iabetes I nsipidus (inability to concentrate the urine), D iabetes M ellitus, O ptic A trophy (degeneration of the nerve to the eye), and ...
Wolfram syndrome (MIM 222300) is the association of juvenile onset diabetes mellitus and optic atrophy, also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus ...
What is exactly the Wolfram Syndrome ... Wolfram Syndrome... (DIDMOAD) a closer look The frequency of those who carry the ressive genetic trait in the US population is ...
DIDMOAD (Wolfram Syndrome) Is diabetes insipidus in combination with smaller than normal optic nerves enough to point to DIDMOAD? (5 Apr 2009) A friend was diagnosed with ...