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Down syndrome critical region: (Abbreviated DSCR) A region on the long (q) arm of chromosome 21 thought to be responsible for some, if not all, of the features of Down syndrome. A number of genes in this region may be involved in the production of the Down syndrome phenotype.
These genes may include the Down syndrome critical region 1 gene or DSCR1 on chromosome 22q11.2; DSCR2 on chromosome 21q22.3; DSCR3 in chromosome 21q22.2; DSCR4 on chromosome 21q22.2; and DSCR5 in chromosome region 21q22.1-q22.2.
Down syndrome critical region: (Abbreviated DSCR) A region on the long (q) arm of chromosome 21 thought to be responsible for some, if not all, of the features of Down ...
Abstract. We have analysed the DNA of 2 patients with many manifestations of Down syndrome and partial duplication of distinct regions of chromosome 21, respectively, q11 ...
Down Syndrome Abstract of the Month: Jan 2005: A chromosome 21 critical region does not cause specific Down syndrome phenotypes Olson LE, Richtsmeier JT, Leszl J, Reeves ...
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity.
Johns Hopkins Medicine Office of Corporate Communications Media Contact: Joanna Downer 410-614-5105; jdowner1@jhmi.edu October 21, 2004. MOUSE STUDY: "CRITICAL" DOWN SYNDROME ...