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Definition of «Kartagener syndrome»

Kartagener syndrome: A genetic syndrome characterized by sinusitis, bronchiectasis (widening and inflammation of the bronchi), dextrocardia (heart on the right side), and infertility. The syndrome is inherited in an autosomal recessive manner.

Kartagener syndrome is usually due to mutation in the gene called DNAI1 (axonemal dynein intermediate chain) which is in chromosome region 9p21-p13. However, linkage studies have mapped the disease gene to 5p and 19q in some families, indicating that Kartagener syndrome is more than one genetic entity.

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