Neuraminidase inhibitor: A drug that inhibits the enzyme called neuraminidase.
For example, oseltamivir (Tamiflu), an antiinfluenza agent, acts by inhibiting the neuraminidase enzyme on the surface of the influenza virus. This prevents the virus from leaving the cell and spreading to others.
Absorbed oseltamivir is metabolized to GS4071 (oseltamivir carboxylate), the active neuraminidase inhibitor, primarily by hepatic esterases. GS4071 has a half-life of 6 ...
Brian J. Smith, 1 Peter M. Colman, 1 Mark Von Itzstein, 2 Basil Danylec, 2 and Joseph N. Varghese 1
Neuraminidase Inhibitor-Resistant Influenza Viruses May Differ Substantially in Fitness and Transmissibility
There are currently two neuraminidase inhibitor drugs licensed for treatment and chemoprophylaxis of influenza; zanamivir [RelenzaÂ®] and oseltamivir [TamifluÂ®].
After discussions over the past year or so, 10th March 2011 saw completion of a formal agreement to bring together the Neuraminidase Inhibitor Susceptibility Network ...