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Definition of «Y-linked»

Y-linkedY-linked

Y-linked: A gene on the Y chromosome. A Y-linked gene is by necessity passed from father to son, since the Y chromosome can only be transmitted by a man to his male progeny.

It has often been said that little is known about whether specific genes are or are not Y-linked. This is no longer true. As of the year 2000, a number of genes were known to be Y-linked including:

  • ASMTY (which stands for acetylserotonin methyltransferase),
  • TSPY (testis-specific protein),
  • IL3RAY (interleukin-3 receptor),
  • SRY (sex-determining region),
  • TDF (testis determining factor),
  • ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
  • AMGL (amelogenin),
  • CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
  • ANT3Y (adenine nucleotide translocator-3 on the Y),
  • AZF2 (azoospermia factor 2),
  • BPY2 (basic protein on the Y chromosome),
  • AZF1 (azoospermia factor 1),
  • DAZ (deleted in azoospermia),
  • RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
  • RBM2 (RNA binding motif protein 2) and
  • UTY (ubiquitously transcribed TPR gene on Y chromosome).

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