ZAP-70: Zeta-chain-associated protein kinase 70. A member of the protein tyrosine kinase family, ZAP-70 is normally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling. ZAP-70 is expressed in T cells and tumors of T-cell lineage. A high level of ZAP-70 expression appears restricted to T-cell proliferative diseases and a subgroup of chronic lymphocytic leukemia (CLL). The ZAP-70 gene is in chromosome 2q12.
ZAP-70 and IgVH Gene Mutation. Date: September 14, 2004. by Chaya Venkat. Two Prognostic Indicators Worth Understanding. Related Articles: What Type of CLL Do You Have?
Terry Hamblin: Hi Gale Dr John Byrd at Ohio State at Columbus is one of the world's foremost CLL experts. FISH stands for Fluorescent In Situ ...
Provides a brief overview of this test including clinical use and background, methodology, test interpretation, and specimen requirements.
ZAP-70: Why Should You Care? Date: April 4, 2003 . by Chaya Venkat . Case Histories of Jane and John . Related Article: ZAP-70 and IgVH Gene Mutation: Worth Understanding
Introduction. Zeta-chain-associated protein (ZAP-70) is a 70kDa adaptor protein that acts quickly after T cell activation to propagate signal.