Trade Names:Amoxicillin- Capsules 250 mg (as trihydrate)- Capsules 500 mg (as trihydrate)- Tablets 500 mg (as trihydrate)- Tablets, chewable 125 mg (as trihydrate)- Tablets, chewable 200 mg (as trihydrate)- Tablets, chewable 250 mg (as trihydrate)- Tablets, chewable 400 mg (as trihydrate)- Powder for oral suspension 125 mg per 5 mL (as trihydrate) when reconstituted- Powder for oral suspension 200 mg per 5 mL (as trihydrate) when reconstituted- Powder for oral suspension 250 mg per 5 mL (as trihydrate) when reconstituted- Powder for oral suspension 400 mg per 5 mL (as trihydrate) when reconstituted
Trade Names:Amoxil- Tablets 875 mg (as trihydrate)- Capsules 500 mg (as trihydrate)- Powder for oral suspension 125 mg per 5 mL (as trihydrate) when reconstituted
Trade Names:DisperMox- Tablets for oral suspension 200 mg- Tablets for oral suspension 400 mg
Trade Names:Moxatag- Tablets, ER 775 mg
Trade Names:Trimox- Capsules 500 mg (as trihydrate)- Powder for oral suspension 125 mg per 5 mL (as trihydrate) when reconstitutedAPO-Amoxi (Canada)Gen-Amoxicillin (Canada)Novamoxin (Canada)Nu-Amoxi (Canada)
Inhibits bacterial cell wall mucopeptide synthesis.
Rapidly absorbed. T max is 1 to 2 h; C max is 3.5 mcg/mL (250 mg dose), 5 mcg/mL (500 mg dose), and approximately 13.8 mcg/mL (875 mg dose).Extended-release
C max is 6.6 mcg/mL; T max is 3.1 h.
Diffuses into most body tissues and fluids; penetration in CNS is poor unless meninges are inflamed. Approximately 20% protein bound.
Half-life is 61.3 min; approximately 60% excreted in the urine within 6 to 8 h as unchanged drug.
Treatment of ear, nose, throat, GU, skin and skin structure, lower respiratory tract, and acute uncomplicated gonorrhea infections caused by susceptible strains of specific organisms. In combination with clarithromycin and/or lansoprazole for the eradication of H. pylori .Moxatag
Treatment of tonsillitis and/or pharyngitis secondary to Streptococcus pyogenes .
Treatment of acute otitis media in children.
Hypersensitivity to penicillins, cephalosporins, or imipenem.
PO 3 g as a single dose.Prepubertal Children (2 yr of age and older)
PO Amoxicillin 50 mg/kg combined with probenecid 25 mg/kg as a single dose.Ear, Nose, Throat, Skin and Skin Structure, GU Tract InfectionsAdults and Children Weighing at least 40 kg Mild to moderate infections
PO 500 mg every 12 h or 250 mg every 8 h.Severe infections
PO 875 mg every 12 h or 500 mg every 8 h.Children (older than 3 mo of age and weighing less than 40 kg) Mild to moderate infections
PO 25 mg/kg/day in divided doses every 12 h or 20 mg/kg/day in divided doses every 8 h.Severe infections
PO 45 mg/kg/day in divided doses every 12 h or 40 mg/kg/day in divided doses every 8 h.H. Pylori EradicationAdults Triple Therapy
PO Amoxicillin 1 g, clarithromycin 500 mg, and lansoprazole 30 mg all given twice daily (every 12 h) for 14 days.Dual therapy
PO Amoxicillin 1 g and lansoprazole 30 mg each given 3 times daily (every 12 h) for 14 days.Impaired Renal FunctionAdults
PO Glomerular filtration rate (GFR) of 10 to 30 mL/min: Administer 500 or 250 mg every 12 h, depending on the severity of the infection.GFR less than 10 mL/min
Administer 500 or 250 mg every 24 h, depending on the severity of the infection.Hemodialysis patients
Administer 500 or 250 mg every 24 h, depending on the severity of the infection, plus an additional dose during and at the end of dialysis.ER tablet
Not recommended in patients with CrCl less than 30 mL/min.Lower Respiratory Tract InfectionsAdults and Children Weighing at least 40 kg
PO 875 mg every 12 h or 500 mg every 8 h.Children (older than 3 mo of age and weighing less than 40 kg)
PO 45 mg/kg/day in divided doses every 12 h or 40 mg/kg/day in divided doses every 8 h.Tonsillitis, PharyngitisAdults and Children 12 yr and older
PO ER tablet: 775 mg once daily, within 1 h of finishing a meal, for 10 days.
Store 250 and 500 mg capsules and 125 and 250 mg unreconstituted powder at or below 68°F.
Store 200 and 400 mg unreconstituted powder, 200 and 400 mg chewable tablets, and 500 and 875 mg tablets at or below 77°F. Dispense in a tight container. Any unused portion of the reconstituted suspension must be discarded after 14 days. Refrigeration is preferable but not required.
Store ER tablets at 77°F; excursions are permitted between 59° and 86°F.
May impair bactericidal effects of amoxicillin.Contraceptives, oral
May reduce efficacy of oral contraceptives.Methotrexate
Methotrexate plasma levels may be elevated, increasing the risk of toxicity.Probenecid
Renal tubular secretion of amoxicillin may be reduced, resulting in increased and prolonged amoxicillin blood levels.Tetracyclines
May impair bactericidal effects of amoxicillin.
May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets (enzyme-based tests [eg, Clinistix , Tes-Tape ] are recommended); false-positive direct Coombs test result in certain patient groups; false-positive protein reactions with sulfosalicylic acid and boiling test, acetic acid test, biuret reaction and nitric acid test (bromphenol blue test, Multistix , is recommended).
Headache (1%); agitation; anxiety; behavioral changes; confusion; convulsions; dizziness; hyperactivity; insomnia.
Acute generalized exanthematous pustulosis; erythema multiforme; erythematous maculopapular rashes; exfoliative dermatitis; mucocutaneous candidiasis; Stevens-Johnson syndrome; toxic epidermal necrolysis; urticaria.
Diarrhea (2%); nausea (1%); black, hairy tongue; hemorrhagic pseudomembranous colitis; tooth discoloration; vomiting.
Vulvovaginal mycotic infection (2%); crystalluria.
Agranulocytosis; anemia; eosinophilia; hemolytic anemia; leukopenia; thrombocytopenia; thrombocytopenic purpura.
Acute cytolytic hepatitis; cholestatic jaundice; hepatic cholestasis; increased ALT and AST.
Anaphylaxis; hypersensitivity vasculitis.
Serum sickness–like reactions.
Periodically assess renal, hepatic, and hematopoietic function during prolonged therapy. Patients diagnosed with gonorrhea should have a serologic test for syphilis at the time of treatment and a follow-up serologic test after 3 mo. In the treatment of UTI, frequent bacteriological and clinical appraisals are necessary.
Category B .
Excreted in breast milk.
Safety and efficacy not established in children younger 12 yr of age.
Differences in response between elderly patients (65 yr of age and older) and younger patients have not been identified.
Serious and occasionally fatal hypersensitivity (eg, anaphylactic) reactions may occur. Use with caution in cephalosporin-sensitive patients because of possible cross-allergenicity.
Dosage reduction may be necessary. Administration is not recommended in patients with severe renal function impairment (CrCl less than 30 mL/min) or patients on hemodialysis.
May result in overgrowth of nonsusceptible bacterial or fungal organisms.
DisperMox tablets for suspension and Amoxil 200 and 400 mg chewable tablets contain phenylalanine.
Consider possibility in patients with diarrhea.
Minimum 10 days required for effective treatment.
Crystalluria, interstitial nephritis.
Copyright © 2009 Wolters Kluwer Health.