Generic Name: articaine and epinephrine (AR ti kane and EP i NEF rin )Brand Names: Septocaine
Articaine and epinephrine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.
Articaine and epinephrine is used as an anesthetic for dental procedures.
Articaine and epinephrine may also be used for other purposes not listed in this medication guide.What is the most important information I should know about articaine and epinephrine?You should not receive articaine and epinephrine if you have ever had an allergic reaction to any type of numbing medicine.
Before receiving this medication, tell your dentist if you have high or low blood pressure, asthma or a sulfite allergy, or a history of seizures.
This medication can cause numbness for an extended period of time. Avoid eating, chewing gum, or drinking hot liquids until the feeling in your mouth has returned completely. Chewing while your mouth is numb could result in a bite injury to your tongue, lips, or inside of your cheek.What should I discuss with my health care provider before receiving articaine and epinephrine?You should not receive articaine and epinephrine if you have ever had an allergic reaction to any type of numbing medicine.
Before receiving articaine and epinephrine, tell your dentist if you are allergic to any drugs, or if you have:
low or high blood pressure;
asthma or a sulfite allergy; or
a history of seizures.
Articaine and epinephrine is given as an injection that is usually placed into the gum area inside your mouth. You will receive this injection in a dentist's office or oral surgical setting.
Since articaine and epinephrine is given as needed before a dental procedure, you are not likely to be on a dosing schedule.
Overdose symptoms may include extreme drowsiness, fainting, seizure (convulsions), shallow breathing, or slow heart rate.
This medication can cause numbness for an extended period of time. Avoid eating, chewing gum, or drinking hot liquids until the feeling in your mouth has returned completely. Chewing while your mouth is numb could result in a bite injury to your tongue, lips, or inside of your cheek.
weak or shallow breathing;
slow heart rate, weak pulse;
feeling like you might pass out;
swelling in your face;
swollen or bleeding gums;
anxiety, confusion, restless feeling, tremors or shaking;
blurred vision, ringing in your ears; or
Less serious side effects may include:
tongue pain or swelling, mouth sores;
nausea, vomiting, constipation, diarrhea, upset stomach;
increased thirst, drooling;
nervousness, dizziness, drowsiness;
ear pain, neck pain, joint or muscle pain;
unusual or unpleasant taste in your mouth;
numbness or tingly feeling;
mild skin rash or itching; or
runny nose, sore throat.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Anesthesia:
Below are the recommended volumes and concentrations of articaine-epinephrine for various types of anesthetic procedures. The dosages suggested below are for normal healthy adults, administered by submucosal infiltration and/or nerve block.Infiltration: 0.5 mL to 2.5 mL or 20 mg to 100 mg of articaine Nerve block: 0.5 mL to 3.4 mL or 20 mg to 136 mg of articaine Oral surgery: 1.0 mL to 5.1 mL or 40 mg to 204 mg of articaineFor most routine dental procedures articaine-epinephrine 1:200,000 is preferred. However, when more pronounced hemostasis is required, articaine-epinephrine 1:100,000 may be used.The above suggested volumes serve only as a guide. Other volumes may be used provided the total maximum recommended dose is not exceeded. The recommended doses above also serve only as a guide to the amount of anesthetic required for most routine procedures. The actual volumes to be used depend on a number of factors such as type and extent of surgical procedure, depth of anesthesia, degree of muscular relaxation, and condition of the patient. In all cases, the smallest dose that will produce the desired result should be given.For normal healthy adults, the maximum dose of articaine administered by submucosal infiltration and/or nerve block should not exceed 7 mg/kg (0.175 mL/kg) or 3.2 mg/lb (0.0795 mL/lb) of body weight, e.g. 7 cartridges (11.9 mL) for a 150 lb. patient.
Usual Geriatric Dose for Anesthesia:
In clinical trials, 54 patients between the ages of 65 and 75 years, and 11 patients 75 years and over received articaine-epinephrine 1:100,000. Among all patients between 65 and 75 years, doses from 0.43 mg/kg to 4.76 mg/kg (0.9 to 11.9 mL) were administered safely to 35 patients for simple procedures and doses from 1.05 mg/kg to 4.27 mg/kg (1.3 to 6.8 mL) were administered safely to 19 patients for complex procedures. Among the 11 patients 75 years and over, doses from 0.78 mg/kg to 4.76 mg/kg (1.3 to 11.9 mL) were administered safely to 7 patients for simple procedures and doses of 1.12 mg/kg to 2.17 mg/kg (1.3 to 5.1 mL) were safely administered to 4 patients for complex procedures.No overall differences in safety or effectiveness were observed between elderly subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.Approximately 6% of patients between the ages of 65 and 75 years and none of the 11 patients 75 years of age or older required additional injections of anesthetic for complete anesthesia compared with 11% of patients between 17 and 65 years old who required additional injections.
Usual Pediatric Dose for Anesthesia:
4 to 10 years of age:The quantity to be injected should be determined by the age and weight of the child and the magnitude of the operation.For children of less than 10 years who have a normal lean body mass and normal body development, the maximum dose may be determined by the application of one of the standard pediatric drug formulas. In any case, the maximum dose of 4% articaine should not exceed the equivalent of 7 mg/kg (0.175 mL/kg) or 3.2 mg/lb (0.0795 mL/lb) of body weight.4 to 16 years of age:In clinical trials, 61 pediatric patients between the ages of 4 and 16 years received articaine-epinephrine 1:100,000. Among these pediatric patients, doses from 0.76 mg/kg to 5.65 mg/kg (0.9 to 5.1 mL) were administered safely to 51 patients for simple procedures and doses between 0.37 mg/kg and 7.48 mg/kg (0.7 to 3.9 mL) were administered safely to 10 patients for complex procedures. However, there was insufficient exposure to articaine-epinephrine 1:100,000 at doses greater than 7 mg/kg in order to assess its safety in pediatric patients. No unusual adverse events were noted in these patients.Approximately 13% of these pediatric patients required additional injections of anesthetic for complete anesthesia. Safety and effectiveness in pediatric patients below the age of 4 years have not been established.
Before receiving articaine and epinephrine, tell your dentist if you are using any of the following drugs:
cold medicine, diet pills, stimulants, or medication to treat ADHD;
medicine to treat a psychiatric disorder (Haldol, Inapsine, Thorazine, Prolixin, Serentil, Mellaril, and others);
medication to treat nausea and vomiting, such as Compazine or Motillium; or
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).
This list is not complete and there may be other drugs that can interact with articaine and epinephrine. Tell your dentist about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.