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Drugs reference index «Urolene Blue»

Urolene Blue

Urolene Blue

Generic Name: methylene blue (Oral route, Intravenous route)

METH-i-leen BLOO

Commonly used brand name(s):

In the U.S.

  • Urolene Blue

Available Dosage Forms:

  • Solution
  • Capsule
  • Tablet

Therapeutic Class: Diagnostic Agent, Kidney Function

Uses For Urolene Blue

Methylene blue is used to treat a condition called methemoglobinemia. This condition occurs when the blood cannot deliver oxygen where it is needed in the body. Methylene blue is also used as a dye to stain certain parts of the body before or during surgery.

Before Using Urolene Blue

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Babies are especially sensitive to the effects of methylene blue. This may increase the chance of side effects during treatment.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of methylene blue in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.


Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency—Methylene blue may cause anemia or make methemoglobinemia worse
  • Kidney disease—In patients with kidney disease methylene blue may accumulate in the body; smaller doses of this medicine may be needed
  • Methemoglobinemia to treat cyanide toxicity—Methylene blue may make cyanide toxicity worse by increasing the amount of cyanide in the blood

Proper Use of Urolene Blue

For patients taking the tablet form of this medicine:

  • Take tablets after meals with a full glass (8 ounces) of water.

Take this medicine only as directed. Do not take more of it and do not take it more often than recommended on the label unless directed by your doctor. To do so may increase the chance of side effects.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For methemoglobinemia:
      • Adults and children—100 to 300 milligrams (mg) a day.
  • For injection dosage form:
    • For methemoglobinemia:
      • Adults and children—Dose is based on body weight or size and must be determined by your doctor. The dose is usually 1 to 2 mg per kilogram (kg) (0.45 to 0.9 mg per pound) of body weight, or 25 to 50 mg per square meter of body surface area, injected into a vein over a period of five minutes. A second dose may be given after one hour, if needed.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Urolene Blue

Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Urolene Blue Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Symptoms of overdose
  • Anxiety
  • back pain
  • bluish fingernails, lips, or skin
  • chest pain
  • chills
  • confusion
  • difficulty in breathing
  • dizziness
  • headache
  • leg pain
  • nausea and vomiting
  • severe sweating
  • stomach pain
  • trembling
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Greenish blue to blue discoloration of urine and stools
Less common
  • Diarrhea
  • nausea and vomiting
  • painful urination or increased need to urinate (with tablet form)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Urolene Blue oral and injection Concise Consumer Information (Cerner Multum)

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