Trade Names:Clorpres- Tablets 0.1 mg clonidine and 15 mg chlorthalidone- Tablets 0.2 mg clonidine and 15 mg chlorthalidone- Tablets 0.3 mg clonidine and 15 mg chlorthalidone
Stimulates central alpha-adrenergic receptors to inhibit sympathetic cardioaccelerator and vasoconstrictor centers.Chlorthalidone
Inhibits reabsorption of sodium and chloride in the proximal portion of the distal convoluted tubules.
Treatment of hypertension; not indicated for initial therapy.
Known hypersensitivity to any component of product or sulfonamide derived drugs.
PO Once or twice/day from a minimum dose of 0.1 mg clonidine plus 15 mg chlorthalidone to a maximum dose of 0.6 mg clonidine plus 30 mg chlorthalidone.
Administer with or without food. Administer with food if GI upset occurs.
Store tablets at controlled room temperature (59° to 86°F). Protect from moisture.
CNS depressive effects may be enhanced with clonidine.Antihypertensive agents
Action may be increased or potentiated by chlorthalidone.Insulin, sulfonylureas (eg, chlorpropamide)
Hypoglycemic effect may be decreased by chlorthalidone, necessitating an increase in dosage.Lithium
Because renal excretion of lithium may be reduced, avoid use if possible.Norepinephrine
Arterial responsiveness to norepinephrine may be decreased.Tricyclic antidepressants
Effects on clonidine may be reduced.
Chlorthalidone may decrease serum protein bound iodine levels without signs of thyroid disturbance.
Orthostatic hypotension; palpitations; tachycardia; bradycardia; Raynaud phenomena; CHF; ECG abnormalities; arrhythmias.Chlorthalidone
Drowsiness; dizziness; sedationClonidine
Malaise; agitation; nervousness; depression; headache; insomnia; vivid dreams; nightmares; restlessness; anxiety; visual and auditory hallucinations; delirium; fatigue; vertigo.Chlorthalidone
Dizziness; paresthesias; headache; xanthopsia.
Rash; pruritus; hives; angioneurotic edema; urticaria; alopecia.Chlorthalidone
Purpura; photosensitivity; rash; urticaria; necrotizing angiitis; toxic epidermal necrolysis.
Dryness and burning of eyes; blurred vision; dryness of nasal mucosa.
Dry mouth; constipation.Clonidine
Nausea; vomiting; anorexia.Chlorthalidone
Anorexia; gastric irritation; nausea; vomiting; cramping; diarrhea; constipation; jaundice; pancreatitis.
Decreased sexual activity; impotence; loss of libido; nocturia; micturition; urinary retention.Chlorthalidone
Leukopenia; agranulocytosis; thrombocytopenia; aplastic anemia.
Transient abnormalities in LFTs.
Weakness; discontinuation syndrome; muscle and joint pain; cramps of the lower limbs; pallor; weakly positive Coombs test; muscle spasm.Chlorthalidone
Monitor blood sugar in diabetic patient when drug is started or dose is changed. Report significant changes to health care provider.BP
Monitor and record BP and pulse. Should hypotension result, hold medication and notify health care provider.
Category C .
Excreted in breast milk.
Safety and efficacy not established.
Use with caution in patients with severe renal disease.
Use with caution, minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Use with caution in patients with severe coronary insufficiency, recent MI, or cerebral vascular disease.
Hypokalemia and other electrolyte abnormalities, including hyponatremia and hypochloremic alkalosis, are common while receiving chlorthalidone. Ensure that serum electrolytes and renal function are monitored before starting therapy and periodically thereafter.
Continue clonidine therapy to within 4 h of surgery and resume as soon as possible thereafter.
General skin rash may develop in patients with localized reaction to the patch if they are switched to oral clonidine.
May be activated or exacerbated.
Hyperuricemia may occur, or frank gout may be precipitated.
Discontinue therapy by reducing the dose gradually over 2 to 4 days to avoid rapid increase in BP.
Hypotension, bradycardia, lethargy, irritability, weakness, somnolence, diminished or absent reflexes, miosis, vomiting, hypoventilation, arrhythmias, apnea, seizures, transient hypertensionChlorthalidone
Nausea, weakness, dizziness, disturbances of electrolyte balance.
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